Lin LL, Nayak B, Osmulski PA, Wang E, Wang CP, Valente PT, Wang CM, Tan X, Santanam N, Wang TL, Gaczynska ME, Kost ER, Huang TH, Kirma NB. PAI-1 uncouples integrin-β1 from the restrain by membrane-bound β-catenin to promote extracellular fibril remodeling in obesity-related neoplasms in obesity-related neoplasms. Cell Rep. 2024 Aug 27;43(8):114527. PMID: 39046873.
Chou CW, Hung CN, Chiu HL, Tan X, Chen M, Chen CC, Saeed M, Hsu CW, Liss MA, Wang CM, Lai Z, Alvarez N, Osmulski PA, Gaczynska ME, Lin LL, Ortega V, Kirma NB, Xu K, Liu Z, Kumar AP, Taverna JA, Velagaleti GVN, Chen CL, Zhang Z, Huang TH. Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination. Nat Commun. 2023 Oct 17;14(1):6569. PMCID: PMC10582093.
Hung CN, Chen M, DeArmond DT, Chiu CH, Limboy CA, Tan X, Kusi M, Chou CW, Lin LL, Zhang Z, Wang CM, Chen CL, Mitsuya K, Osmulski PA, Gaczynska ME, Kirma NB, Vadlamudi RK, Gibbons DL, Warner S, Brenner AJ, Mahadevan D, Michalek JE, Huang TH, Taverna JA. AXL-initiated paracrine activation of pSTAT3 enhances mesenchymal and vasculogenic supportive features of tumor-associated macrophages. Cell Rep. 2023 Sep 26;42(9):113067. PMCID: PMC10577802.
Kusi M, Zand M, Lin LL, Chen M, Lopez A, Lin CL, Wang CM, Lucio ND, Kirma NB, Ruan J, Huang TH. and Mitsuya K. 2-Hydroxyglutarate destabilizes chromatin regulatory landscape and lineage fidelity to promote cellular heterogeneity. Cell Rep. 2022 Jan 11;38(2):110220. 38:110220. PMCID: PMC8811753.
Lin LL, Makwana S, Chen M, Wang, C.-M., Gillette, L. H., Huang, T. H.-M., Burney, Richard O. N., B.-J., Kirma, N. B. Cellular junction and mesenchymal factors delineate an endometriosis-specific response of endometrial stromal cells to the mesothelium. Mol. Cell Endocrinol. 2022 Jan 1:539:111481. PMID: 34624439.
Lin LL, Kost ER, Lin CL, Valente P, Wang CM, Kolonin MG, Daquinag AC, Tan X, Lucio N, Hung CN, Wang CP, Kirma NB, Huang TH. PAI-1-dependent inactivation of SMAD4-modulated junction and adhesion complex in obese endometrial cancer. Cell Rep. 2020 Oct 13;33(2):108253. PMCID: PMC7641039.
Chuang HC, Lin HY, Liao PL, Huang CC, Lin LL, Hsu WM, and Chuang JH. Immunomodulator poly (I:C) enhances the inhibitory effect of 13 cis-retinoic-acid on neuroblastoma through TLR3-related immunogenic-apoptotic response. Lab Invest. 2020 Apr;100(4):606-618. PMID: 31857701.
Polusani SR*, Huang YW*, Huang G*, Chen C.-W., Wang, CM, Lin LL, Osmulski PA, Lucio ND, Liu L, Hsu YT, Zhou Y, Lin CL, Aguilera-Barrantes I, Valente PT, Kost ER, Chen CL, Shim EY, Lee SE, Ruan J, Gaczynska ME, Yan P, Goodfellow PJ, Mutch DG, Jin VX, Nicholson BJ, Huang TH, Kirma NB. Adipokines deregulate cellular communication via epigenetic repression of gap junction loci in obese endometrial cancer. Cancer Res. 2019 Jan 1;79(1):196-208. PMCID: PMC6705596.
Lin LL, Huang CC, Wu MT, Hsu WM, Chuang JH. Innate immune sensor LGP2 suppresses tumor cell growth and functions as a prognostic marker in neuroblastoma. Cancer Sci. 2018 Nov;109(11):3494-3502. PMCID: PMC6215871.
Lin LL, Huang CC, Wu CL, Wu MT, Hsu WM, Chuang JH. Downregulation of c-Myc is involved in TLR3-mediated tumor death of neuroblastoma xenografts. Lab. Invest. 2016 Jul;96(7):719-30. PMID: 27183205.
Jen J, Lin LL, Chen HT, Liao SY, Lo FY, Tang YA, Su WC, Salgia R, Hsu CL, Huang HC, Juan HF, Wang YC. Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer. Oncogene 2016 May 5;35(18):2357-69. PMCID: PMC4865475.
Huang CC, Wang SY, Lin LL, Wang PW, Chen TY, Hsu WM, Lin TK, Liou CW, Chuang JH. Glycolytic inhibitor 2-deoxyglucose simultaneously targets cancer and endothelial cells to suppress neuroblastoma growth. Dis. Model. Mech. 2015 Oct 1;8(10):1247-54. PMCID: PMC4610240.
Hsu WM, Huang CC, Lee HY, Wu PY, Wu MT, Chuang HC, Lin LL, Chuang JH. MDA5 complements TLR3 in suppression of neuroblastoma. Oncotarget 2015 Sep 22;6(28):24935-46. PMCID: PMC4694805.
Lin LL, Hsu CL, Hu CW, Ko SY, Hsieh HL, Huang HC, Juan HF. Integrating phosphoproteomics and bioinformatics to study Brassinosteroid-regulated phosphorylation dynamics in Arabidopsis. BMC Genomics 2015 Jul 18;16(1):533. PMCID: PMC4506601.
Wang SY, Wei YH, Shieh DB, Lin LL, Cheng SP, Wang PW, Chuang JH. 2-Deoxy-D-Glucose can complement doxorubicin and sorafenib to suppress the growth of papillary thyroid carcinoma cells. PLoS One 2015 Jul 2;10(7):e0130959. PMCID: PMC4489888.
Lin LL, Huang HC, Juan HF, 2014 TCSBSG. Circadian systems biology in metazoan. Brief Bioinform. 2015 Nov;16(6):1008-24. PMID: 25758249.
Lin LL, Hsia CR, Hsu CL, Huang HC, Juan HF. Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells. BMC Genomics 2015 Feb 5;16(1):41. PMCID: PMC4328042.
Lin LL, Huang HC, Juan HF, 2013 TCSBSG. Deciphering molecular determinants of chemotherapy in gastrointestinal malignancy using systems biology approaches. Drug Discov. Today 2014 Sep;19(9):1402-9. PMID: 24793142.
Lin LL, Wu CC, Huang HC, Chen HJ, Hsieh HL, Juan HF. Identification of microRNA 395a in 24-epibrassinolide-regulated root growth of Arabidopsis thaliana using microRNA arrays. Int. J. Mol. Sci. 2013 Jul 9;14(7):14270-86. PMCID: PMC3742243.
Lin LL, Wang YH, Lai CY, Chau CL, Su GC, Yang CY, Lou SY, Chen SK, Hsu KH, Lai YL, Wu WM, Huang JL, Liao CH, Juan HF. Systems biology of meridians, acupoints, and Chinese herbs in disease. Evid. Based. Complement Alternat. Med. 2012:2012:372670. PMCID: PMC3483864.
Lin LL, Huang HC, Juan HF. Revealing the molecular mechanism of gastric cancer marker Annexin A4 in cancer cell proliferation using exon arrays. PLoS One 2012;7(9):e44615. PMCID: PMC3436854.
Lin LL, Huang HC, Ogihara S, Wang JT, Wu MC, McNeil PL, Chen CN, Juan HF. Helicobacter pylori disrupt host cell membranes, initiating a repair response and cell proliferation. Int. J. Mol. Sci. 2012;13(8):10176-10192. PMCID: PMC3431852.
Lin LL, Huang HC, Juan, HF. Discovery of biomarkers for gastric cancer: a proteomics approach. J. Proteomics 2012 Jun 18;75(11):3081-97. PMID: 22498886.
Lin LL, Chen CN, Lin WC, Lee PH, Chang KJ, Lai YP, Wang JT, Juan HF. Annexin A4: A novel molecular marker for gastric cancer with Helicobacter pylori infection using proteomics approach. Proteomics Clin. Appl. 2008 Apr;2(4):619-34. PMID: 21136859.
Chen YR, Juan HF, Huang HC, Huang HH, Lee YJ, Liao MY, Tseng CW, Lin LL, Chen JY, Wang MJ, Chen JH, Chen YJ. Quantitative Proteomic and Genomic Profiling Reveals Metastasis-Related Protein Expression Patterns in Gastric Cancer Cells. J. Proteome Res. 2006 Oct;5(10):2727-42. PMID: 17022644.
