Donna M. Lehman, Ph.D.
Associate Professor
Department of Medicine
Population Science and Prevention Program, Mays Cancer Center, Genetics Discipline Coordinator, LSOM Undergraduate Medical Education
Dr. Lehman’s area of expertise is human genomics. Her teaching focus is in medical genomics, preparing students in all healthcare professions to integrate genomic information into patient care. Her research program addresses the health challenges of diabetes/obesity and prostate cancer through a long-standing translational program utilizing state-of-the-art stem cell and multi-omics methods in large cohorts of subjects and patients to identify and characterize genetic risk factors for metabolic disorders and prostate cancer among minority populations.
-
Professional Background
Education
- 1999 - PhD - Cellular and Structural Biology - University of Texas Health Science Center
- 1994 - MS - Computational Biology - University of Tennessee, Oak Ridge National Lab
- 1985 - BS - Biology (Summa Cum Laude) - Texas A&M University
Highlights
2016 Nominee UTHSA Presidential Excellence in Teaching Award: Department of Cellular and Structural Biology.
Appointments
- 9/2008-Present - Associate Professor of Medicine - UTHSA
-
-
Instruction & Training
1/2018 - Present - Genetics and Genetic Epidemiology - The University of Texas Health Science Center4/2017 - Present - Stem Cell Biology - The University of Texas Health Science Center12/2014 - Present - Fundamentals of Biomedical Sciences - The University of Texas Health Science Center2/2014 - Present - Musculoskeletal Dermatology - The University of Texas Health Science Center9/2013 - Present - Molecules to Medicine - The University of Texas Health Science Center9/2013 - 8/2020 - UTHSCSA5/2010 - Present - Post-Doctoral Student Supervision - UT Health Science Center San Antonio9/2008 - Present - Medical Genetics - The University of Texas Health Science Center6/2006 - Present - UTHSCSA
-
Research & Grants
My lab: proficient in the generation and use of human induced pluripotent stem (iPS) cells and their differentiation into CNS neurons, adipocytes and cardiomyocytes (for many clinical disorders, the disease relevant tissue is not accessible for functional analyses); developed and published a unique protocol for generating neuronal cultures that model hypothalamic neurons of the ARC which are key neurons in regulating whole body energy metabolism through mechanisms such as regulation of appetite, browning of fat, and gluconeogenesis; using our novel human models, we study CNS control of obesity, glucose homeostasis and metabolic disease as well as hypothalamic neurogenesis and have recently published unique findings on obesity genetics.
GrantsProject #: 1R01DK114661-01A, Funding Agency: NIH/NIDDK, Title: Human hypothalamic neuronal epigenomics and risk for obesity, Status: ACTIVE, Period: 09/2018 - 09/2022, Role: Principal Investigator.
Project #: 1U01DK085524-06, Funding Agency: NIH, Title: Discovery of Functional Variants in Type 2 Diabetes Genes in Mexican Americans, Status: ACTIVE, Period: 04/2015 – 04/2021, Role: Co-Principal Investigator.
Project #: 1 UL1 RR025767-0, Funding Agency: NIH, Title: Institute for Integration of Medicine and Science/Research Education, Status: Active, Period: 05/2008 - present, Role: Contributor.
Project #: R56DK10915801A1, Funding Agency: NIH/NIDDK, Title: Temporal epigenetic regulation in human hypothalamic neurons and body weight, Status: COMPLETE, Period: 09/2017 - 08/2019, Role: Principal Investigator.
Project #: 5P20CA165589, Funding Agency: NIH/NCI, Title: The Cancer Bioinformatics Initiative: A UTSA/UTHSCSA Partnership (1 of 2), Status: COMPLETE Period: 09/2012 - 08/2017, Role: Co-Investigator. -
Service
School
01/2018 - Present: MEDI6067Genomic Healthcare, Post-graduate, Course director
04/2017 - Present: CSBL6059 Stem Cells and Regenerative Medicine, Graduate
12/2014 - Present: INTD5000 Fundamentals of Biomedical Sciences, Graduate
02/2014 - Present CIRC6013 Form & Function, Post Graduate
09/2013 - Present CIRC5007 Molecules to Medicine, Undergraduate/GraduateInstitutional
09/2013 - Present: Discipline Coordinator for Genetics for UTHSCSA SOM Undergraduate Medical Education (UME) Program.
06/2006 – Present: Committee on Graduate Studies (COGS) member for Master of Science in Clinical Investigation (MSCI) Program. The COGS oversees all aspects of the program related to program requirements, curriculum development, student admissions and progress as well as credentialing of graduate faculty.
11/2006-05/2019: Postdoctoral Fellowship Mentor and Supervisor -
Publications
Abstract
Diaz-Badillo A, Lopez-Alvarenga JC, Totomoch A, Hernandez-Ruiz J, Akhtar F, Mummidi S, Arya R, Jenkinson CP, Comuzzie AG, Curran J, Dyer TD, Lehman DM, Blangero J, Duggirala R. Relationship between Sarcopenic Obesity and Cardiometabolic risk in Mexican-Americans; The role of adiponectin; 2019 Nov. (Obesity supplement). Hernandez -Ruiz J, Lopez-Alvarenga JC, Garces MJ, Garibay-Nieto N, Villanueva-Ortega E, Gloria-Quiepo, Resendez RG, Arya R, Mummidi S, Comuzzie AG, Jenkinson CP, Lehman DM, Lynch JL, Hale DE, DeFronzo RA, Blangero J, Duggirala R. Different Obesity-Related Liver Function Profiles Exhibited by Mexican-American and Mexican children; 2019 Nov. (Obesity supplement). Alvarenga JL, arya r, chittoor g, puppala s, farook v, resendez r, lehman dm, defronzo r, mummidi s, jenkinson c, lynch j, blangero j, duggirala r. Acanthosis Nigricans as a Composite Marker of Cardiometabolic Risk and Its Complex Association with Obesity and Insulin Resistance in Mexican American Children; 2019 Jun. (Diabetes). Kumar S, Curran JE, Lehman DM, Duggirala R, Glahn D, Blangero J. Parkinson?s disease gene identification using differential gene expression analysis of iPSC generated neural stem cells; 2017 Jan. (2017 Annual Meeting of the American Society of Human Genetics). Diego VP, Fowler S, Puppala S, Farook VS, Chittoor G, Resendez R, Alvarenga JC, Mummidi S, Vanamala J, Almasy L, Curran JE, Comuzzie, AG, Lehman DM, Jenkinson C, Lynch JL, DeFronzo RA, Blangero J, Hale DE, Duggirala R, Arya R. Genotype-by-multivariate dietary environment interaction effects on cardiometabolic risk factors in Mexican American children: The SAFARI Study; 2016 Nov. (Am J Hum Genet). Arya R, Puppala S, Fowler S, Srinivas M, Farook VS, Dyer T, Almeida M, Peralta J, Resendez, R, Lopez-Alvarenga JC, Jenkinson CP, Comuzzie AG, Goring HHH, Mahaney M, Almasy L, Lehman DM, Curran JE, Duggirala R, Blangero J. Genome-wide association analysis localizes a novel locus for abdominal obesity in Mexican Americans; 2016 Nov. (Obesity). Wang C, Lehman D, Lam Y, Kuhn J, Mahalingam D, Weitman S, Hernandez J, Lorenzo C, Downs J, Espinoza S, Ramirez A. Metformin reduces prostate cancer disparity in men with type 2 diabetes?; 2015 Jun. (Diabetes; vol. 64, no. S1). Lehman DM, Yao L, Liu Y, Ayala I, Mahesula S, Chen Y, Kokovay E. TCF7L2 in Hypothalamic Neurogenesis in Mice and Men; 2015 Jan. (Diabetes; vol. 64, no. S1). Liu Y, Yao L, Chen Y, and Lehman DM. Human induced pluripotent stem cell-derived neurons - a novel model to investigate genetic control of metabolic homeostasis UTHSCSA; 2014 May. (IIMS 5th Annual Frontiers in Translational Science Symposium). Jun G, Almeida M, Cingolani P, Wood, AR, Fuchsberger C, Teslovich TM, Dyer TD, Curran JE, Grunstad J, Blackwell TW, Lehman DM, Grossman R, Lincoln SE, Laramie JM, Boehnke M, McCarthy MI, Frayling TM, Sladek R, Duggirala R, Blangero J, Abecasis GR. Detecting functional rare variants relating to type 2 diabetes using deep whole genome sequencing; 2012 Jun. (Diabetes; vol. 61, no. S1). Almeida M, Jun G, Teslovich TM, Wood AR, Frayling TM, Fuchsberger C, Cingolani P, Blackwell TW, Dyer TD, Curran JE, Lehman DM, Sladek R, Grunstad J, Grossman R, Laramie JM, Lincoln SE, McCarthy MI, Boehnke M, Duggirala R, Abecasis GR, Blangero J, T2D-GENES Consortium. Whole genome sequencing to discover type 2 diabetes risk genes in Mexican American pedigrees: T2D-GENES consortium project 2; 2012 Jun. (Diabetes; vol. 61, no. S1). Quillen EE, Duggirala R, Curran JE, Carless MC, Dyer TD, Goring HHH, Almasy L, Lehman DM, Blangero J. Neurological and signaling pathways are associated with variation in skin color: Wiley-Blackwell; 2012 Jan. (Am J Phys Anthropol; vol. 147, no. S54).
Journal Article
Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, Chen S, Contreras-Cubas C, Cordova E, Correa A, Cortes M, DeFronzo RA, Dolan L, Drews KL, Elliott A, Floyd JS, Gabriel S, Garay-Sevilla ME, Garcia-Ortiz H, Gross M, Han S, Heard-Costa NL, Jackson AU, J?rgensen ME, Kang HM, Kelsey M, Kim BJ, Koistinen HA, Kuusisto J, Leader JB, Linneberg A, Liu CT, Liu J, Lyssenko V, Manning AK, Marcketta A, Malacara-Hernandez JM, Martinez-Hernandez A, Matsuo K, Mayer-Davis E, Mendoza-Caamal E, Mohlke KL, Morrison AC, Ndungu A, Ng MCY, O'Dushlaine C, Payne AJ, Pihoker C; Broad Genomics Platform, Post WS, Preuss M, Psaty BM, Vasan RS, Rayner NW, Reiner AP, Revilla-Monsalve C, Robertson NR, Santoro N, Schurmann C, So WY, Soberon X, Stringham HM, Strom TM, Tam CHT, Thameem F, Tomlinson B, Torres JM, Tracy RP, van Dam RM, Vujkovic M, Wang S, Welch RP, Witte DR, Wong TY, Atzmon G, Barzilai N, Blangero J, Bonnycastle LL, Bowden DW, Chambers JC, Chan E, Cheng CY, Cho YS, Collins FS, de Vries PS, Duggirala R, Glaser B, Gonzalez C, Gonzalez ME, Groop L, Kooner JS, Kwak SH, Laakso M, Lehman DM, Nilsson P, Spector TD, Tai ES, Tuomi T, Tuomilehto J, Wilson JG, Aguilar-Salinas CA, Bottinger E, Burke B, Carey DJ, Chan JCN, Dupuis J, Frossard P, Heckbert SR, Hwang MY, Kim YJ, Kirchner HL, Lee JY, Lee J, Loos RJF, Ma RCW, Morris AD, O'Donnell CJ, Palmer CNA, Pankow J, Park KS, Rasheed A, Saleheen D, Sim X, Small KS, Teo YY, Haiman C, Hanis CL, Henderson BE, Orozco L, Tusie-Luna T, Dewey FE, Baras A, Gieger C, Meitinger T, Strauch K, Lange L, Grarup N, Hansen T, Pedersen O, Zeitler P, Dabelea D, Abecasis G, Bell GI, Cox NJ, Seielstad M, Sladek R, Meigs JB, Rich SS, Rotter JI; DiscovEHR Collaboration; CHARGE; LuCamp; ProDiGY; GoT2D; ESP; SIGMA-T2D; T2D-GENES; AMP-T2D-GENES, Altshuler D, Burtt NP, Scott LJ, Morris AP, Florez JC, McCarthy MI, Boehnke M. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls Nature 2019 May;epub. Ramstetter MD, Dyer TD, Lehman DM, Curran JE, Duggirala R, Blangero J, Mezey J, Williams AL. Inferring identical by descent sharing of sample ancestors promotes high resolution relative detection Am J Hum Genet 2018 Jul;103(1):30-44. Arya R, Farook VS, Fowler SP, Puppala S, Chittoor G, Resendez RG, Mummidi S, Vanamala J, Almasy L, Curran JE, Comuzzie AG, Lehman DM, Jenkinson CP, Lynch JL, DeFronzo RA, Blangero J, Hale DE, Duggirala R, Diego VP. Genetic and environmental (physical fitness and sedentary activity) interaction effects on cardiometabolic risk factors in Mexican American children and adolescents Genet Epidemiol 2018 Jun;42(4):378-393. Jun G, Manning A, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Cingolani P, Gaulton KJ, Dyer T, Blackwell TW, Chen H, Chines PS, Choi S, Churchhouse C, Fontanillas P, King R, Lee S, Lincoln SE, Trubetskoy V, DePristo M, Fingerlin T, Grossman R, Grundstad J, Heath A, Kim J, Kim YJ, Laramie J, Lee J, Li H, Liu X, Livne O, Locke AE, Maller J, Mazur A, Morris AP, Pollin TI, Ragona D, Reich D, Rivas MA, Scott LJ, Sim X, Tearle RG, Teo YY, Williams AL, Zollner S, Curran JE, Peralta J, Akolkar B, Bell GI, Burtt NP, Cox NJ, Florez JC, Hanis CL, McKeon C, Mohlke KL, Seielstad M, Wilson JG, Atzmon G, Below JE, Dupuis J, Nicolae DL, Lehman D, Park T, Won S, Sladek R, Altshuler D, McCarthy MI, Duggirala R, Boehnke M, Frayling TM, Abecasis GR, Blangero J. Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees Proc Natl Acad Sci U S A 2018 Jan;115(2):379-384. Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Muller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SCJ, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MCY, Palmer ND, Balkau B, Stančakova A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JMM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VKL, Park KS, Saleheen D, So WY, Tam CHT, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA, Thameem F, Wilson G, Wong TY, Nj?lstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney ASF, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, J?rgensen ME, J?rgensen T, Ladenvall C, Justesen JM, Karajamaki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, de Angelis MH, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O`Rahilly SP, Palmer CNA, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvanen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RCW, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJF, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Magi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai E. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls Sci Data 2017 Dec;4. Mercader JM, Liao RG, Bell AD, Dymek Z, Estrada K, Tukiainen T, Huerta-Chagoya A, Moreno-Macias H, Jablonski KA, Hanson RL, Walford GA, Moran I, Chen L, Agarwala V, Ordo?ez-Sanchez ML, Rodriguez-Guillen R, Rodriguez-Torres M, Segura-Kato Y, Garcia-Ortiz H, Centeno-Cruz F, Barajas-Olmos F, Caulkins L, Puppala S, Fontanillas P, Williams AL, Bonas-Guarch S, Hartl C, Ripke S; Diabetes Prevention Program Research Group, Tooley K, Lane J, Zerrweck C, Martinez-Hernandez A, Cordova EJ, Mendoza-Caamal E, Contreras-Cubas C, Gonzalez-Villalpando ME, Cruz-Bautista I, Mu?oz-Hernandez L, Gomez-Velasco D, Alvirde U, Henderson BE, Wilkens LR, Le Marchand L, Arellano-Campos O, Riba L, Harden M; Broad Genomics Platform, Gabriel S; T2D-GENES Consortium, Abboud HE, Cortes ML, Revilla-Monsalve C, Islas-Andrade S, Soberon X, Curran JE, Jenkinson CP, DeFronzo RA, Lehman DM, Hanis CL, Bell GI, Boehnke M, Blangero J, Duggirala R, Saxena R, MacArthur D, Ferrer J, McCarroll SA, Torrents D, Knowler WC, Baier LJ, Burtt N, Gonzalez-Villalpando C, Haiman CA, Aguilar-Salinas CA, Tusie-Luna T, Flannick J, Jacobs SBR, Orozco L, Altshuler D, Florez JC; SIGMA T2D Genetics Consortium. A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes Diabetes 2017 Nov;66(11):2903-2914. Ramstetter MD, Dyer TD, Lehman DM, Curran JE, Duggirala R, Blangero J, Mezey JG, Williams AL. Benchmarking Relatedness Inference Methods with Genome-Wide Data from Thousands of Relatives Genetics 2017 Sep;207(1):75-82. Manning A Highland HM Gasser J Sim X Tukiainen T Fontanillas PGrarup NRivas MAMahajan ALocke AE Cingolani P Pers TH Vi?uela A Brown AA Wu Y Flannick J Fuchsberger C Gamazon ER Gaulton KJ Im HK Teslovich TM Blackwell TW Bork-Jensen JBurtt NP Chen YGreen T Hartl C Kang HM Kumar A Ladenvall C Ma C Moutsianas LPearson RDPerry JRB Rayner NW Robertson NR Scott LJ van de Bunt M Eriksson JG Jula A Koskinen S Lehtimaki T Palotie A Raitakari OT Jacobs SBR Wessel J Chu AY Scott RA Goodarzi MO Blancher C Buck G Buck D Chines PS Gabriel S Gjesing APGroves CJ Hollensted MHuyghe JR Jackson AU Jun G Justesen JMMangino MMurphy J Neville M Onofrio R Small KSStringham HM Trakalo J Banks E Carey J Carneiro MO DePristo M Farjoun Y Fennell T Goldstein JI Grant G Hrabe de Angelis M Maguire J Neale BM Poplin R Purcell S Schwarzmayr T Shakir K Smith JD Strom TM Wieland T Lindstrom J Brandslund I Christensen C Surdulescu GLLakka TA Doney ASF Nilsson P Wareham NJ Langenberg C Varga TV Franks PW Rolandsson O Rosengren AH Farook VS Thameem F Puppala S Kumar S Lehman DM Jenkinson CP Curran JE Hale DE Fowler SP Arya R DeFronzo RA Abboud HE Syvanen AC Hicks PJ Palmer ND Ng MCY Bowden DW Freedman BI Esko T Magi R Milani L Mihailov E Metspalu A Narisu N Kinnunen L Bonnycastle LL Swift A Pasko D Wood AR Fadista J Pollin TI Barzilai N Atzmon G Glaser B Thorand B Strauch K Peters A Roden M Muller-Nurasyid M Liang L Kriebel J Illig T Grallert H Gieger C Meisinger C Lannfelt L Musani SK Griswold M Taylor HA Jr Wilson G Sr Correa A Oksa HScott WRAfzal UTan ST Loh M Chambers JC Sehmi J Kooner JSLehne BCho YSLee JYHan BGKarajamaki A Qi Q Qi L Huang J Hu FB Melander O Orho-Melander M Below JE Aguilar D Wong TY Liu J Khor CC Chia KS Lim WY Cheng CY Chan E Tai ES Aung T Linneberg A Isomaa B Meitinger T Tuomi T Hakaste L Kravic J J?rgensen ME Lauritzen T Deloukas P Stirrups KE Owen KR Farmer AJ Frayling TM O'Rahilly SP Walker M Levy JC Hodgkiss DHattersley AT Kuulasmaa T Stančakova A Barroso I Bharadwaj D Chan J Chandak GR Daly MJ Donnelly PJ Ebrahim SB Elliott P Fingerlin T Froguel P Hu C Jia W Ma RCW McVean GPark T Prabhakaran D Sandhu M Scott JSladek R Tandon N Teo YY Zeggini E Watanabe RM Koistinen HA Kesaniemi YA Uusitupa M Spector TDSalomaa V Rauramaa R Palmer CNA Prokopenko I Morris AD Bergman RN Collins FS Lind L Ingelsson E Tuomilehto J Karpe F Groop L J?rgensen T Hansen T Pedersen OKuusisto J Abecasis G Bell GI Blangero J Cox NJ Duggirala R Seielstad M Wilson JG Dupuis J Ripatti S Hanis CL Florez JC Mohlke KL Meigs JB Laakso M Morris AP Boehnke M Altshuler D McCarthy MI Gloyn AL Lindgren CM. A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk Diabetes 2017 Jul;66(7):2019-2032. Farook VS, Reddivari L, Mummidi S, Puppala S, Arya R, Lopez-Alvarenga JC, Fowler SP, Chittoor G, Resendez RG, Kumar BM, Comuzzie AG, Curran JE, Lehman DM, Jenkinson CP, Lynch JL, DeFronzo RA, Blangero J, Hale DE, Duggirala R, Vanamala JK
. Genetics of serum carotenoid concentrations and their correlation with obesity-related traits in Mexican American children Am J Clin Nutr 2017 Jul;106(1):52-58. Yao L, Liu Y, Qiu Z, Kumar S, Curran JE, Blangero J, Chen Y, Lehman DM. Molecular profiling of human iPS-derived hypothalamic neurons provides developmental insights to genetic loci for body weight regulation J. Neuroendocrinol 2017 Feb;29(2). Wang CP, Lehman DM, Lam YF, Kuhn JG, Mahalingam D, Weitman S, Lorenzo C, Downs JR, Stuart EA, Hernandez J, Thompson IM, Ramirez AG. Metformin for Reducing Racial/Ethnic Difference in Prostate Cancer Incidence for Men with Type II Diabetes Cancer Prev Res 2016 Oct;9(10):779-787. Blangero J, Teslovich TM, Sim X, Almeida MA, Jun G, Dyer TD, Johnson M, Peralta JM, Manning A, Wood AR, Fuchsberger C, Kent JW Jr, Aguilar DA, Below JE, Farook VS, Arya R, Fowler S, Blackwell TW, Puppala S, Kumar S, Glahn DC, Moses EK, Curran JE, Thameem F, Jenkinson CP, DeFronzo RA, Lehman DM, Hanis C, Abecasis G, Boehnke M, Goring H, Duggirala R, Almasy L; T2D-GENES Consortium. Omics-squared: human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19 BMC Proc 2016 Oct;10:71-77. Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, O`Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T, Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K, Zhao F, Zou J, Pierce-Hoffman E, Berghout J, Cooper DN, Deflaux N, DePristo M, Do R, Flannick J, Fromer M, Gauthier L, Goldstein J, Gupta N, Howrigan D, Kiezun A, Kurki MI, Moonshine AL, Natarajan P, Orozco L, Peloso GM, Poplin R, Rivas MA, Ruano-Rubio V, Rose SA, Ruderfer DM, Shakir K, Stenson PD, Stevens C, Thomas BP, Tiao G, Tusie-Luna MT, Weisburd B, Won HH, Yu D, Altshuler DM, Ardissino D, Boehnke M, Danesh J, Donnelly S, Elosua R, Florez JC, Gabriel SB, Getz G, Glatt SJ, Hultman CM, Kathiresan S, Laakso M, McCarroll S, McCarthy MI, McGovern D, McPherson R, Neale BM, Palotie A, Purcell SM, Saleheen D, Scharf JM, Sklar P, Sullivan PF, Tuomilehto J, Tsuang MT, Watkins HC, Wilson JG, Daly MJ, MacArthur DG; Exome Aggregation Consortium. Analysis of protein-coding genetic variation in 60,706 humans Nature 2016 Aug;536(7616):285-291. Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JR, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Fernandez Tajes J, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Muller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SC, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MC, Palmer ND, Balkau B, Stancakova A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VK, Park KS, Saleheen D, So WY, Tam CH, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, van der Schouw YT, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA Jr, Thameem F, Wilson G Sr, Wong TY, Nj?lstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney AS, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, J?rgensen ME, J?rgensen T, Ladenvall C, Justesen JM, Karajamaki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, Hrabe de Angelis M, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O`Rahilly SP, Palmer CN, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvanen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RC, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJ, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Magi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Dugg. The genetic architecture of type 2 diabetes Nature 2016 Aug;536(7614):41-47. Nicholson AM, Finch NA, Almeida M, Perkerson RB, van Blitterswijk M, Wojtas A, Cenik B, Rotondo S, Inskeep V, Almasy L, Dyer T, Peralta J, Jun G, Wood AR, Frayling TM, Fuchsberger C, Fowler S, Teslovich TM, Manning AK, Kumar S, Curran J, Lehman D, Abecasis G, Duggirala R, Pottier C, Zahir HA, Crook JE, Karydas A, Mitic L, Sun Y, Dickson DW, Bu G, Herz J, Yu G, Miller BL, Ferguson S, Petersen RC, Graff-Radford N, Blangero J, Rademakers R. Prosaposin is a regulator of progranulin levels and oligomerization Nat. Commun 2016 Jun;7. Hanson RL, Leti F, Tsinajinnie D, Kobes S, Puppala S, Curran JE, Almasy L, Lehman DM, Blangero J, Duggirala R, DiStefano JK. The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and differentially affects cleavage of ANGPTL3 Mol Genet Metab 2016 Jun;118(2):128-137. Americans.Chittoor G, Kent JW Jr, Almeida M, Puppala S3, Farook VS, Cole SA, Haack, Goring HH, MacCluer JW, Curran JE, Carless MA, Johnson MP, Moses EK5, Almasy L4, Mahaney MC4, Lehman DM, Duggirala R, Comuzzie AG, Blangero, Voruganti VS. GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans BMC Genomics 2016 Apr;.
Kim YJ, Lee J, Kim BJ; T2D-Genes Consortium, Park T. A new strategy for enhancing imputation quality of rare variants from next-generation sequencing data via combining SNP and exome chip data BMC Genomics 2015 Dec;16. Wang H, Luo X, Yao L, Lehman DM, Wang P. Improvement of Cell Survival During Human Pluripotent Stem Cell Definitive Endoderm Differentiation Stem Cells Dev 2015 Nov;24(21):2536-2546. Blackburn A, Almeida M, Dean A, Curran JE, Johnson MP, Moses EK, Abraham LJ, Carless MA, Dyer TD, Kumar S, Almasy L, Mahaney MC, Comuzzie A, Blangero J, Lehman DM, Goring HH. Effects of copy number variable regions on local gene expression in white blood cells of Mexican Americans Eur J Hum Genet 2015 Jan;23(9):1229-1235. Deidre A. Winnier; Marcel Fourcaudot; Luke Norton; Muhammad A Abdul-Ghani; Shirley L Hu; Vidya S Farook; Dawn K Coletta; Satish Kumar; Sobha Puppala; Geetha Chittoor; Thomas D Dyer; Rector Arya; Melanie Carless; Donna M Lehman; Joanne E Curran; Douglas T Cromack; Devjit Tripathy; John Blangero; Ravindranath Duggirala; Harald H Goring; Ralph A DeFronzo; Christopher Paul Jenkinson. Transcriptomic Identification of ADH1B as a Novel Candidate Gene for Obesity and Insulin Resistance in Human Adipose Tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES) PLOS ONE 2015 Jan;10(4). Farook VS, Reddivari L, Chittoor G, Puppala S, Arya R, Fowler SP, Hunt KJ, Curran JE, Comuzzie AG, Lehman DM, Jenkinson CP, Lynch JL, DeFronzo RA, Blangero J, Hale DE, Duggirala R, Vanamala J. Metabolites as novel biomarkers for childhood obesity-related traits in Mexican-American children Pediatr Obes 2015 Jan;10(4):320-327. Blackburn AN, Dean AK, Lehman DM. Imputation in families using a heuristic phasing approach BMC Proc 2014 Jun;8:16-16. Blackburn A, Goring HHH, Dean A, Carless MA, Dyer T, Kumar S, Fowler S, Curran JE, Almasy L, Mahaney M, Comuzzie A, Duggirala R, Blangero J, Lehman DM. Utilization of extended pedigree information for discovery and confirmation of copy number variable regions among Mexican Americans European Journal of Human Genetics 2013 Jan;21(4):404-409. Lehman DM, Lorenzo C, Hernandez J, Wang CP. Statin use as a moderator of metformin effect on risk for prostate cancer among type 2 diabetic patients Diabetes Care 2012 May;35(5):1002-1007.