James Donald Lechleiter, Ph.D.

Federal

Funding Agency NIH Title San Antonio Biomedical Education and Research (SABER) Status Active Period 7/2015 - 3/2020 Role Principal Investigator Grant Detail PD/PIs: Dr. James Lecheiter, Dr. Babatunde Oyajobi, and Dr. Linda McManus. This is a multi-investigator grant for an Institutional Research and Academic Career Development Award (IRACDA (K12). The SABER program is a collaboration between UTHSCSA and our Hispanic-serving partners, Saint Mary?s University (StMU) and Our Lady of the Lake University (OLLU). The goal of SABER is to prepare exceptional postdoctoral researchers and teachers for an academic career that closes the gap between the aspirations and achievements of Hispanic students while at the same time, increasing interest in careers in biomedical research among undergraduates. Funding Agency NIH Title San Antonio Cancer Institute (SACI)- Optical Imaging Core Status Active Period 9/2014 - 9/2019 Role Co-Investigator Grant Detail Imaging Core Director Funding Agency NIH-NIA Title CSF-1 Gene Expression In Osteoclast Biology Status Active Period 9/2013 - 6/2018 Role Co-Investigator Grant Detail PI-S. Abboud-Werner
The major goals of this project are 1) ) Determine the effect of CSF-1cKO in osteocytes on bone phenotype and redox state during aging. 2) Determine the role of Nox4 in osteocytes of CSF-1cKO mice and mechanisms by which CSF-1 regulates osteocyte survival. 3) Determine the ability of CSF-1 isoforms to rescue bone defects in CSF-1cKO mice.